Biochemistry at The Biology Project

B12/Folate Problem set

Question 1: "Folate trapping" in a vitamin B12 deficiency

Insufficient Vitamin B12 often creates an apparent folate deficiency by trapping which folate intermediate?

A. folic acid
B. dihydrofolate (DHF)
C. tetrahydrofolate (THF)
D. N5-methyl THF
The suggested mnemonic to remember this is that, in the intersection between the folate and B12 pathways, it is methyl-folate that donates the methyl group to B12 to make methyl-B12. Of course, if there is no B12 around, this cannot happen, and the folate becomes trapped. The next question asks a bit more about methyl-B12...
E. N10-formyl THF

[Problem 1] [Tutorial] [Problem 2]

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January 31, 2000
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