Regulation of Carbohydrate Metabolism Problem Set
Question 1: Liver Enzymes Affected by InsulinTutorial to help answer the question
Insulin facilitates energy storage in liver. Which enzymes of carbohydrate metabolism are coordinately regulated in liver in response to insulin signaling?
Six enzymes shown in red (including all five listed in question) are affected by insulin, via three different mechanisms. All but glycogen phosphorylase are stimulated. However, note that PFK-2 is one activity of a bifunctional enzyme - the other "half" of this two-headed beast will come up later in this tutorial.
The University of Arizona
March 16, 2001
Revised: August, 2004
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