Carbohydrate Metabolism Regulation Problem Set
Question 4: Insulin Regulation of GlucokinaseTutorial to help answer the question
Glucokinase is also regulated by insulin in liver, but not via phosphorylation. How is this regulation accomplished?
When glucose concentrations become very high or are chronically high, insulin has another card to play in order to clear glucose from the blood. Recall that glucokinase, a liver enzyme, has a relatively high Km for glucose, and therefore only really comes into action when glucose concentrations are high. This enzyme is well suited for removing glucose from the blood for two reasons.
Now, before we move on to consider glucagon action, this is a good time to take
a last look at the whole picture of insulin action in liver, which includes coordinated
regulation of six enzymes in order to achieve glucose uptake and storage (just
follow the green arrows!).
The Biology Project Home > Biochemistry > Regulation of Carbohydrate Metabolism > Problem Set
The University of Arizona
March 16, 2001
Revised: August, 2004
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