The Biology Project: Biochemistry

Large Molecules Problem Set

Problem 7: Weak forces involved in interactions between macromolecules


Two macromolecules, such as proteins, can adhere tightly and specifically to each other. How can weak forces such as electrostatic attraction, van der Waals bonds, hydrogen bonds, and hydrophobic forces lead to such strong adherence?
A. adherence can be quite strong by having many weak forces involved in molecular adhesion.
The additive effect of many weak forces, including hydrogen bonds, hydrophobic interactions, van der Waals forces, and ionic bonds provide significant energy for biological structure.
B. the weak forces can become very strong once non-polar groups are excluded from the inside of the molecules.
C. the weak forces are readily converted to covalent bonds, thus leading to strong adherence between molecules.
D. if the weak forces are correctly aligned they can become as strong as covalent bonds.
E. adhesion is strong because the weak forces can be involved in condensation reactions.

Problem 7 Tutorial Problem 8

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