Large Molecules Problem Set
Problem 10: Protein-protein interactions
What change should disrupt the interaction between proteins 1 and 2 the most? the least?
Proteins 1 and 2 interact strongly. A significant part of the interaction is between the amino acid side chains shown below.
Assume that a mutation occurs in protein 2 that changes the amino acid shown above to one of the amino acids shown below.
A. The most: aspartic acid; the least: leucine
B. The most: lysine; the least: serine
C. The most: Serine; the least: aspartic acid
D. The most: lysine; the least: aspartic acid
E. The most: aspartic acid; the least: serine
The Biology Project
Department of Biochemistry and Molecular Biophysics
The University of Arizona
Revised: February 5, 2003
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