Problem 1: Regulation
The addition of a phosphate group by a protein kinase is a key regulatory
switch for many biological processes. How can regulation be achieved by this
||Phosphorylation can change the three dimensional structure of a
protein, and thus alter the number of and orientation of weak
interactions that could be made in biologically relevant interactions.
This can change the specificity of protein binding to its target as a
Biological recognition requires multiple weak interactions between
molecules, and protein kinases alter the process by adding a phosphate. A typical cell in your body may have
more than 100 different protein kinases
The Biology Project
Department of Biochemistry and Molecular Biophysics
The University of Arizona
Revised: January 28, 2003
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