Blackett Family DNA Activity 2

DNA Profile Frequency Calculations

In this activity, you can calculate the probability for some of the DNA profiles you have been studying. The following set of data are tables of allele frequency for the three STR loci D3S1358, vWA, and FGA for a combined, Caucasian population. The frequency data come from the web site of the Royal Canadian Mounted Police.

Based on a population database of Caucasians developed by Bob Blackett and colleagues in Arizona, Bob can calculate the genotype frequency of his combined profile for the three STR loci D3S1358, vWA, and FGA to be 6 x 10^-5. Compare this frequency with the frequency you calculate from the Royal Canadian Mounted Police data. For help with this calculation, review the DNA Profile Frequency Calculation page.

If you feel really ambitious, retrieve additional frequency data for the other 10 STR Loci from the web site of the Royal Canadian Mounted Police and calculate the genotype frequency for all 13 STR loci for one or more individuals from this study.

As an alternative to doing all of the arithmetic yourself, you can Calculate a profile's Random Match Probability using the RCMP on-line calculator.

Introduction : Overview | STR P | CODIS | Analysis | Inheritance | Frequency Calc.

Activities : Pedigree | Collect data | Paternity testing | Missing person | RCMP freq. calc.