Blackett Family DNA Activity 2
DNA Profile Frequency Calculations
In this activity, you can calculate the probability for some of the DNA profiles you have been studying. The following set of data are tables of allele frequency for the three STR loci D3S1358, vWA, and FGA for a combined, Caucasian population. The frequency data come from the web site of the Royal Canadian Mounted Police.
1. What is the Probability for a 3-Locus DNA profile?
Based on a population database of Caucasians developed by Bob Blackett and colleagues in Arizona, Bob can calculate the genotype frequency of his combined profile for the three STR loci D3S1358, vWA, and FGA to be 6 x 10-5. Compare this frequency with the frequency you calculate from the Royal Canadian Mounted Police data. For help with this calculation, review the DNA Profile Frequency Calculation page.2. Genotype Frequency for the 13 CODIS STR Loci.
If you feel really ambitious, retrieve additional frequency data for the other 10 STR Loci from the web site of the Royal Canadian Mounted Police and calculate the genotype frequency for all 13 STR loci for one or more individuals from this study.3. Check your answers.
As an alternative to doing all of the arithmetic yourself, you can Calculate a profile's Random Match Probability using the RCMP on-line calculator.
University of Arizona
October 27, 2000
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