Antibody Structure Problem Set

Problem 5. Antibody/antigen binding

Tutorial to help answer the question

Glutamine 121 protrudes away from the surface of the antigen. The exposed residue can fit into a depression in the antibody. Association leads to the formation of __________ between antigen and antibody?

A. covalent bonds
B. ionic bonds
C. hydrophobic attractions
D. hydrogen bonds


Multiple weak interactions between the antibody and antigen create a strong binding affinity. The orientation of the antibody's amino acids maximizes hydrogen bonding between the antigen and the antibody.

Gln 121 (green) fits into a depression created by the 3-D structure of the antibody. Hydrogen bonds are indicated by yellow lines.
Close up of hydrogen bond between amino acids from antibody and antigen.


The Biology Project
The University of Arizona
Tuesday, June 20, 2000
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