Introduction to Immunology
Allergies result from the production of ______
directed against an antigen.
IgE binds to the surface of a class
of white blood cells called mast cells. The presence of
antigen that binds to the IgE leads to the release of
granules by the mast cells that contain a number of mediators
of inflammation, including histamine. These factors are
important in immune response that protect us from parasites,
including helminths (worms). Some humans are more likely
to make an IgE response to non-pathogenic antigens, including
pollens. These individuals suffer from allergies caused
by IgE-stimulated mast cell degranulation.
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