The Biology Project: Immunology

Introduction to Immunology

Problem 9. Clonal selection theory

The clonal selection theory of antibody diversity says:


B cell precursors randomly rearrange variable coding parts of antibody genes. Afterwards, antigen binds to a clone with specific membrane antibody, resulting in differentiation to antibody secreting plasma cells

Gene rearrangements occur prior to association with antigen. A random process, but which produces many antibody coding genes. Antigen binding to a specific antibody can lead to the clonal selection and production of soluble antibody.
B. The antigen causes a nonspecific clone of B lymphocytes to proliferate and secrete antibody molecules capable of binding to any foreign antigen
C. Antigen causes the growth of a clone of lymphocytes which then rearrange DNA, creating a gene coding for a specific antibody
D. A clone of macrophages with specific receptor for antigen phagocytoses antigen, then rearranges DNA to generate specific antibody-coding genes


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