Recombinant DNA Technology Problem Set
Problem 8: Huntington's disease
The data below shows the results of electrophoresis of PCR fragments amplified using probes for the site which has been shown to be altered in Huntington's disease. The male parent, as shown by the black box, got Huntington's disease when he was 40 years old. His children include 6 (3,5,7,8,10,11) with Huntington's disease, and the age at which the symptoms first began is shown by the number above the band from the PCR fragment.
In the Figure showing data on Huntington's disease, which of the following conclusions is valid:
Relationship between the number of CAG repeats and the age of onset of the disease
University of Arizona
Updated: July 15, 1999
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