Nucleic Acids and the Genetic Material Problem Set 1

Problem 1 Tutorial: DNA, the genetic material

Which scientists first gave experimental evidence that DNA is the genetic material?  

Avery, MacLeod, and McCarty, 1944

Avery, MacLeod, and McCarty's landmark study followed up on the work of Griffith (diagrammed below).

  1. Purified S strain extracts to characterize the transforming principle.

  2. Material was resistant to proteases; it contained no lipid or carbohydrate.

  3. If DNA in the extract is destroyed, the transforming principle is lost.

  4. Pure DNA isolated from the S strain extract transforms R strain.

  5. Avery cautiously suggested that DNA was the genetic material.

  6. This was the first experimental evidence that DNA is the genetic material.



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Thursday, October 3, 1996
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