William J. Grimes, Ph.D.
- B.S. Chemistry, University of Colorado
- National Science Foundation Graduate Fellow: Univ. of Colo.; Laboratory of Dr. Peter Albersheim
- National Institute of Health Postdoctoral Fellow: Massachusetts Institute of Technology; Laboratory of Dr. Phillips W. Robbins
- Assistant Professor; Department of Biochemistry, University of Arizona
- Associate Professor; Department of Biochemistry, University of Arizona
- Professor; Department of Biochemistry, University of Arizona
- Faculty- Arizona Cancer Center
Honors and Awards
- Outstanding Teacher Award, Univ. Ariz. College of Medicine 1980 for Teaching Biochemistry to Medical Students
- Faculty of Sciences, Innovative Teaching Award 1986 Developing and teaching Freshman Biology, U. of A.
- Pima County- Service Award for Mountain Rescue Activities 1986
- Faculty of Sciences, Distinguished Advisor Award 1990 - Undergraduate Program in Biol. Sciences U of A
- Faculty of Sciences, Distinguished Teaching Award 1992- Developed Computerized Teaching Programs for Undergraduate Biology U of A.
- El Paso Natural Gas Foundation Faculty Achievement Award 1994.
- Faculty of Sciences, Distinguished Career Teaching Award 1997.
- College of Sciences Award for Distinguished Achievement in Science Education Through the Biology Project 2002.
- Chong, A.S.F., E.M.Hersh, and W.J. Grimes. "Blocking of Lymphokine Activated Killer (LAK) Cell Mediated Cytotoxicity by Cell-sized Beads Bearing Tumor Cell Proteins." J. Imm. 141, 4418-4424, 1988.
- Chong, A. S. F., P. Scuderi, W. J. Grimes and E. M. Hersh. "Tumor Targets Stimulate Il-2 Activated Killer Cells to Produce Interferon-Gamma and Tumor Necrosis Factor." Journal of Immunology. 142: 2133-2139, 1989.
- Chong, A. S. F., A. Aleksijevic, P. Scuderi, E. M. Hersh and W. J. Grimes. "Phenotypic and Functional Analysis of Lymphokine-Activated Killer (LAK) Cell Clones - Ability of CD-3+, LAK Cell Clones to Produce Interferon-Gamma and Tumor Necrosis Factor upon Stimulation with Tumor Targets." Cancer Immunology Immunotherapy. 29: 270-278, 1989.
- Hersh, E. M., P. Scuderi, W. J. Grimes, A. Chong, J. L. Brailey, C. R. Gschwind and S. E. Salmon. "Cytostatic and Cytotoxic Activity of Lymphokine-Activated Killer Cell Supernatants." Cancer Immunology Immunotherapy. 30: 65-70, 1989.
- Chong, A. S. F., B. Ybarrondo, W. J. Grimes, E. M. Hersh and P. Scuderi. "Phenotypic analyses of lymphokine-activated killer cells that release interferon gamma and tumor necrosis factor alpha." Cancer Imm. Immunother. 31: 255-259, 1990.
- Chong, A. S. F., D. E. Bier, W. J. Grimes and E. M. Hersh. "Gamma-irradiated peripheral blood mononuclear cells can express LAK activity." Int. J. Cell Cloning. 9: 23-32, 1991.
- Chong, A. S. F., J. K. Pinkard, K. S. Lam, P. Scuderi, E. M. Hersh and W. J. Grimes. "Ability of cell-sized beads bearing tumor cell-membrane proteins to stimulate LAK cells to secrete interferon-gamma and tumor necrosis factor alpha." Cell. Immunol. 134: 96-110, 1991.
- Seftor, R. E. B., E. A. Seftor, W. J. Grimes, L. A. Liotta, W. G. Stetler-Stevenson, D. R. Welch and M. J. C. Hendrix. "Human melanoma cell invasion is inhibited in vitro by swainsonine and deoxymannojirimycin with a concomitant decrease in collagenase IV expression." Melanoma Res. 1: 43-54, 1991.
- Punt, C.J.A., J.A.M. Barbuto, W.J. Grimes., and E.M. Hersh. "Antitumor Antibody Produced by Human Tumor-infiltrating and Peripheral Blood B Lymphocytes." Cancer Imm. Immunother. 38, 225-231 (1994)
- Smith, M.H., Lam, K.S., Hersh, E.M., Lebl, M., and W.J. Grimes. "Peptide Sequences Binding to MHC Class I Proteins. Molecular Imm. 31, 1431-1437 (1994)
- Barbuto, J.A., Grimes, W.J. and E.M. Hersh. Antibodies to TNF: a component of B-cell immune responses with a role in tumor-host interaction. Cancer Imm. Immunother. Csancer Immunol. Immunother. 40, 31-36 (1995)
- Zhang, H., Lake, D.F., Barbuto, J.A., Bernstein, R.M., Grimes, W.J., and Hersh, E.M. A Human Monoclonal Anti-melanoma Single Chain Fv(scFv) Antibody Derived from Tumor Infiltrating Lymphocytes. Cancer Research 55, 3584-3591 (1995).
- Grimes, W., Chambers, L., Kubo, K., and Narro, M.L., A Laboratory Experience Simulating Transmission of a Viral Disease (AIDS) Detected by a Modified
ELISA Reaction. The American Biology Teacher 60, 362 (1998).
- Smith, M., Nuara, A., Egen, J. Sirjani, D., Lam, K., and Grimes, Baculoviral expressed HLA class I heavfy chains used to screen a syntheticd peptide
library for Allele-Specific peptide binding motifs. Mol. Imm. 35, 1033 (1998).
- Grimes, W., Willott, E., Lapointe, M., Katcher, J. Honors Biology on Thursday Evenings. The National Honors Reports. 22, 20-23 (2001).
- Sara O. Dionne1, Douglas F. Lake, William J. Grimes and Margaret H. Smith, Identification of HLA-Cw6.02 and -Cw7.01 allele-specific binding motifs
by screening synthetic peptide libraries. Immunogenetics 56, 391-399 (2004).
Educational Activities on the World Wide Web
I have produced numerous tutorial activities, lectures and laboratories
associated with the teaching of Biology. These can be found at http://www.blc.arizona.edu
and http://www.biology.arizona.edu. The work includes:
- Lectures for Biology 181 students.
- Problem sets with associated tutorials.
- Problem sets to be submitted by students for grading.
- Full background and details of the HIV/AIDS laboratory, including a current discussion of recent progress in the treatment of AIDS.