William J. Grimes, Ph.D.

Professional Experience

B.S. Chemistry, University of Colorado
National Science Foundation Graduate Fellow: Univ. of Colo.; Laboratory of Dr. Peter Albersheim
National Institute of Health Postdoctoral Fellow: Massachusetts Institute of Technology; Laboratory of Dr. Phillips W. Robbins
Assistant Professor; Department of Biochemistry, University of Arizona
Associate Professor; Department of Biochemistry, University of Arizona
Professor; Department of Biochemistry, University of Arizona
Faculty- Arizona Cancer Center

Honors and Awards

  1. Outstanding Teacher Award, Univ. Ariz. College of Medicine 1980 for Teaching Biochemistry to Medical Students
  2. Faculty of Sciences, Innovative Teaching Award 1986 Developing and teaching Freshman Biology, U. of A.
  3. Pima County- Service Award for Mountain Rescue Activities 1986
  4. Faculty of Sciences, Distinguished Advisor Award 1990 - Undergraduate Program in Biol. Sciences U of A
  5. Faculty of Sciences, Distinguished Teaching Award 1992- Developed Computerized Teaching Programs for Undergraduate Biology U of A.
  6. El Paso Natural Gas Foundation Faculty Achievement Award 1994.
  7. Faculty of Sciences, Distinguished Career Teaching Award 1997.
  8. College of Sciences Award for Distinguished Achievement in Science Education Through the Biology Project 2002.

Selected References

  1. Chong, A.S.F., E.M.Hersh, and W.J. Grimes. "Blocking of Lymphokine Activated Killer (LAK) Cell Mediated Cytotoxicity by Cell-sized Beads Bearing Tumor Cell Proteins." J. Imm. 141, 4418-4424, 1988.

  2. Chong, A. S. F., P. Scuderi, W. J. Grimes and E. M. Hersh. "Tumor Targets Stimulate Il-2 Activated Killer Cells to Produce Interferon-Gamma and Tumor Necrosis Factor." Journal of Immunology. 142: 2133-2139, 1989.

  3. Chong, A. S. F., A. Aleksijevic, P. Scuderi, E. M. Hersh and W. J. Grimes. "Phenotypic and Functional Analysis of Lymphokine-Activated Killer (LAK) Cell Clones - Ability of CD-3+, LAK Cell Clones to Produce Interferon-Gamma and Tumor Necrosis Factor upon Stimulation with Tumor Targets." Cancer Immunology Immunotherapy. 29: 270-278, 1989.

  4. Hersh, E. M., P. Scuderi, W. J. Grimes, A. Chong, J. L. Brailey, C. R. Gschwind and S. E. Salmon. "Cytostatic and Cytotoxic Activity of Lymphokine-Activated Killer Cell Supernatants." Cancer Immunology Immunotherapy. 30: 65-70, 1989.

  5. Chong, A. S. F., B. Ybarrondo, W. J. Grimes, E. M. Hersh and P. Scuderi. "Phenotypic analyses of lymphokine-activated killer cells that release interferon gamma and tumor necrosis factor alpha." Cancer Imm. Immunother. 31: 255-259, 1990.

  6. Chong, A. S. F., D. E. Bier, W. J. Grimes and E. M. Hersh. "Gamma-irradiated peripheral blood mononuclear cells can express LAK activity." Int. J. Cell Cloning. 9: 23-32, 1991.

  7. Chong, A. S. F., J. K. Pinkard, K. S. Lam, P. Scuderi, E. M. Hersh and W. J. Grimes. "Ability of cell-sized beads bearing tumor cell-membrane proteins to stimulate LAK cells to secrete interferon-gamma and tumor necrosis factor alpha." Cell. Immunol. 134: 96-110, 1991.

  8. Seftor, R. E. B., E. A. Seftor, W. J. Grimes, L. A. Liotta, W. G. Stetler-Stevenson, D. R. Welch and M. J. C. Hendrix. "Human melanoma cell invasion is inhibited in vitro by swainsonine and deoxymannojirimycin with a concomitant decrease in collagenase IV expression." Melanoma Res. 1: 43-54, 1991.

  9. Punt, C.J.A., J.A.M. Barbuto, W.J. Grimes., and E.M. Hersh. "Antitumor Antibody Produced by Human Tumor-infiltrating and Peripheral Blood B Lymphocytes." Cancer Imm. Immunother. 38, 225-231 (1994)

  10. Smith, M.H., Lam, K.S., Hersh, E.M., Lebl, M., and W.J. Grimes. "Peptide Sequences Binding to MHC Class I Proteins. Molecular Imm. 31, 1431-1437 (1994)

  11. Barbuto, J.A., Grimes, W.J. and E.M. Hersh. Antibodies to TNF: a component of B-cell immune responses with a role in tumor-host interaction. Cancer Imm. Immunother. Csancer Immunol. Immunother. 40, 31-36 (1995)

  12. Zhang, H., Lake, D.F., Barbuto, J.A., Bernstein, R.M., Grimes, W.J., and Hersh, E.M. A Human Monoclonal Anti-melanoma Single Chain Fv(scFv) Antibody Derived from Tumor Infiltrating Lymphocytes. Cancer Research 55, 3584-3591 (1995).

  13. Grimes, W., Chambers, L., Kubo, K., and Narro, M.L., A Laboratory Experience Simulating Transmission of a Viral Disease (AIDS) Detected by a Modified ELISA Reaction. The American Biology Teacher 60, 362 (1998).

  14. Smith, M., Nuara, A., Egen, J. Sirjani, D., Lam, K., and Grimes, Baculoviral expressed HLA class I heavfy chains used to screen a syntheticd peptide library for Allele-Specific peptide binding motifs. Mol. Imm. 35, 1033 (1998).

  15. Grimes, W., Willott, E., Lapointe, M., Katcher, J. Honors Biology on Thursday Evenings. The National Honors Reports. 22, 20-23 (2001).

  16. Sara O. Dionne1, Douglas F. Lake, William J. Grimes and Margaret H. Smith, Identification of HLA-Cw6.02 and -Cw7.01 allele-specific binding motifs by screening synthetic peptide libraries. Immunogenetics 56, 391-399 (2004).

Educational Activities on the World Wide Web

I have produced numerous tutorial activities, lectures and laboratories associated with the teaching of Biology. These can be found at http://www.blc.arizona.edu and http://www.biology.arizona.edu. The work includes:
  1. Lectures for Biology 181 students.
  2. Problem sets with associated tutorials.
  3. Problem sets to be submitted by students for grading.
  4. Full background and details of the HIV/AIDS laboratory, including a current discussion of recent progress in the treatment of AIDS.